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Cambridge Reproduction SRI


My research uses human population genetics approaches (e.g GWAS) to highlight the genes and biological pathways determining variation in reproductive traits and diseases. We have a particular interest in using these approaches to identify the mechanisms linking reproductive ageing to later life cardio-metabolic disease.


Selected publications:

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nature Genetics (2019)

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics (2017)

Genome-wide associations for birth weight and correlation with adult disease. Nature (2016)

Physical and neurobehavioral determinants of reproductive onset and success. Nature Genetics (2016)

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics (2015)

Rare coding variants and X-linked loci associated with age at menarche. Nature Communications (2015)

Genetic determinants of puberty timing in men and women: shared genetic aetiology between sexes and with health-related outcomes. Nature Communications (2015)

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nature Communications (2015)

Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche. Nature (2014)

Meta-analyses identify 13 loci associated with age at menopause and highlights DNA repair and immune pathways Nature Genetics (2012)

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics (2009).