My research uses human population genetics approaches (e.g GWAS) to highlight the genes and biological pathways determining variation in reproductive traits and diseases. We have a particular interest in using these approaches to identify the mechanisms linking reproductive ageing to later life cardio-metabolic disease.
Selected publications:
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nature Genetics (2019)
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics (2017)
Genome-wide associations for birth weight and correlation with adult disease. Nature (2016)
Physical and neurobehavioral determinants of reproductive onset and success. Nature Genetics (2016)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics (2015)
Rare coding variants and X-linked loci associated with age at menarche. Nature Communications (2015)
Genetic determinants of puberty timing in men and women: shared genetic aetiology between sexes and with health-related outcomes. Nature Communications (2015)
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nature Communications (2015)
Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche. Nature (2014)
Meta-analyses identify 13 loci associated with age at menopause and highlights DNA repair and immune pathways Nature Genetics (2012)
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics (2009).
