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Cambridge Reproduction SRI


Current Position

Head of Department

Department of Obstetrics and Gynaecology

Telephone: +44 (0)1223 336871



Current Research Interests

  • Control of myometrial contractility
  • Control of fetal maturation and adaptation at birth
  • Use of statistical modeling to predict and understand causes of adverse pregnancy outcome


Brief CV

  • Graduated DSc Glasgow University (2012)
  • Elected a Fellow of the Academy of Medical Science (2010)
  • Appointed Head of Department of Obstetrics and Gynaecology (January 2004), University of Cambridge
  • Appointed Professor of Obstetrics and Gynaecology, (September 2001), University of Cambridge
  • Honorary Consultant in Maternal-Fetal Medicine, Addenbrooke’s NHS trust, Cambridge (since September 2001)
  • Completed sub-specialist training Maternal-Fetal Medicine (2001), Glasgow
  • Graduated PhD (2001), University of Glasgow
  • Wellcome Advanced Clinical Training Fellowship (3 years, 1996-1999) with Prof Peter Nathanielsz, Cornell University, Ithica, NY, USA. Molecular Pharmacology of prostanoid receptors and parturition.
  • Graduated MRCOG (1995)
  • Graduated MD (1995), Glasgow
  • Wellcome Clinical Training Fellowship (1992-1993) with Prof Ian McGrath, Glasgow University, Pharmacology of the ductus arteriosus
  • Graduated MB ChB (1990), University of Glasgow
  • Graduated BSc Physiology (intercalated) (1987), first class honours, University of Glasgow


Key Publications

Walker KF, Bugg GJ, McPherson M, McCormick C, Grace N, Wildsmith C, Bradshaw L, Smith GC, Thornton JG, and 35/39 Trial Group (2016). Randomised trial of labor induction in women 35 years of age or older. New England Journal of Medicine. 374(9): 813-822

Flenady V, Wojcieszek AM, Middleton P, Ellwood D, Erwich JJ, Coory M, Khong TY, Silver RM, Smith GC, Boyle FM, Lawn JE, Blencowe H, Leisher SH, Gross MM, Horey D, Farrales L, Bloomfield F, McCowan L, Brown SJ, Joseph KS, Zeitlin J, Reinebrant HE, Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell AE, Storey C, Sadler L, Petersen S, Frøen JF, Goldenberg  RL, Lancet Ending Preventable Stillbirths Study Group, and Lancet Stillbirths in High-income Countries Investigator Group (2016). Stillbirths: recall to action in high-inome countries. Lancet. 387(10019): 691-702

Sovio U, White IR, Dacey A, Pasupathy D, and Smith GC. (2015). Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the pregnancy outcome prediction (POPs) study: a prospective cohort study. Lancet. 386(10008): 2089-2097

Ilodromiti S, Mackay DF, Smith GC, Pell JP, and Nelson SM (2014). Apgar score and the risk of cause-specific infant mortality: a population-based cohort study. Lancet. 385(9956): 1749-1755�

Oliver-Williams C, Fleming M, Monteath K, Wood AM, and Smith GCS (2013). Changes in association between previous therapeutic abortion and preterm birth in Scotland, 1980 to 2008:a historical cohort study. PLoS Medicine.� 10:e1001481

Wood AM, Pasupathy D, Pell JP, Fleming M, and Smith GCS (2012). Trends in socioeconomic inequalities in the risk of sudden infant death syndrome, other causes of infant mortality and stillbirth in Scotland: a population based study.� BMJ.� 344: e1552

Flenady V, Koopmans L, Middleton P, Froen JF, Smith GCS, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, and Ezzati M (2011). Major risk factors for stillbirth in high-income countries: a systematic review and meta-ananlysis. Lancet.� 377: 1331-1340

Pasupathy D, Wood AM, Pell JP, Mechan H, Fleming M, and Smith GCS (2010). Time of birth and risk of neonatal death at term: a retrospective cohort study.� BMJ.� 341: c3498

Smith GCS (2010). First-Trimester determination of complications of late pregnancy.� JAMA.� 303(6): 561-562

Pasupathy D, Wood AM, Pell JP, Mechan H, Fleming M, and Smith GCS (2009). Rates of and Factors associated with delivery related perinatal death among term infants in Scotland.� JAMA.� 302: 6

Smith GCS, Cordeaux Y, White IR, Pasupathy D, Missfelder-Lobos H, Pell JP, Charnock-Jones DS, and Fleming M (2008). The effect of delaying childbirth on primary cesarean section rates. PLoS Medicine. 5(7):e144

Smith GCS, Celik E, To M, Khouri O and Nicolaides KH (2008). Cervical length at mid-pregnancy and the risk of primary cesarean delivery during labor at term.� N. Eng J. Med.� 358: 1346-1353

Smith GCS, and Fretts R (2007). Seminar: Stillbirth.� Lancet.� 370: 1715-1725

Smith GCS, Wood AM, Pell JP, and Dobbie R (2005). Sudden infant death syndrome and complications in other pregnancies.� Lancet.366: 2107-2111

Smith GCS, Crossley JA, Aitken DA, Pell JP, Cameron AD, Connor JM, and Dobbie R (2004). First trimester placentations and the risk of antepartum stillbirth.� JAMA.� 292: 2249-2254

Smith GCS, Wood AM, Pell JP, White IR, Crossley JA, and Dobbie R (2004). Second trimester maternal serum levels of alpha-fetoprotein and the subsequent risk of sudden infant death syndrome.� N. Eng. J. Med.� 351: 978-986

Smith GCS, Pell JP, and Dobbie R (2003). Caesarean section and the risk of unexplained stillbirth in subsequent pregnancy.� Lancet.� 362: 1779-1784

Smith GCS, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, and Connor JM (2002). Early pregnancy origins of low birth weight.� Nature.� 417: 916

Smith GCS, Pell JP, Cameron AD, and Dobbie R (2002). Risk of perinatal death associated with delivery after previous cesarean section.� JAMA.� 287: 2684-2690

Smith GCS, Pell JP, and Walsh D (2001). Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births.� Lancet.� 357: 2002-2006

Smith GCS, Smith MFS, McNay MB, and Flemig JEE (1998). First trimester growth and the risk of low birth weight.� N. Eng. J. Med. 339: 1817-1822

Smith GCS (1998). The pharmacology of the ductus arteriosus.� Pharmacological Reviews.� 50: 35-58