My research focuses on understanding the fundamental mechanisms of brain aging and DNA damage repair. In my PhD work, I investigated aging in the naked mole rat brain through multi-omic analysis, combining genomic, transcriptomic, epigenetic, and proteomic approaches. I also developed expertise in high-throughput CRISPR screening and DNA damage repair pathway analysis, particularly in the context of trinucleotide repeat expansion in Huntington's disease.
The intersection of DNA damage, aging, and reproductive health represents a critical yet understudied area. Female fertility dramatically declines with age, largely due to accumulated DNA damage in oocytes and the deterioration of reproductive tissues. The DNA repair mechanisms I study in neurodegeneration share significant overlap with those crucial for maintaining oocyte quality and preventing age-related fertility decline.
I am eager to expand my research into reproductive biology and women's reproductive aging, as this field represents a crucial intersection of my interests in aging mechanisms and human health.
