Professor Wolf Reik

Babraham Institute

Epigenetics Programme

Our lab works on epigenetic mechanisms of gene regulation in mammalian development. We particularly focus on understanding the mechanisms and biological functions of epigenetic reprogramming which occurs on a large scale in germ cells and in early embryos. We think that this may be related to the acquisition of pluripotency and potentially totipotency in the zygote, transgenerational epigenetic inheritance, imprinting, and transposon regulation. We are interested in the molecular mechanisms by which epigenetic marks, particularly DNA methylation, can be erased from the genome in the process of reprogramming. We believe that a mechanistic understanding of reprogramming will provide novel insights and translational approaches to regenerative medicine, ageing, and cancer.

• Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.
  Cell Rep   PubMed
  31 Jan 2017
• Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.
  Genome Biol   PubMed
  18 Apr 2016
• Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass.
  Stem Cell Reports   PubMed
  12 Apr 2016
• Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity.
  Nat Methods   PubMed
  01 Mar 2016
• Maternal DNA Methylation Regulates Early Trophoblast Development.
  Dev Cell   PubMed
  25 Jan 2016

(272 publications for this researcher)

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